Cristiano Ronaldo scored his 400th goal for Real Madrid as Zinedine Zidane's side closed in on a first La Liga title since 2012, easing to a 4-1 win over Sevilla on Sunday while Neymar hit a hat-trick for Barcelona, which thrashed Las Palmas 4-1.
"Nobody is speaking about the title in the dressing room", said Zidane, who led Madrid to last year's Champions League in his first season in charge. We are not going to relax. "We are Real Madrid and we must show we are the best team and the champions".
If Ronaldo's second had gone someway towards confirming the result, Aspas' red card two minutes after the hour-mark seemed to have effectively sealed it.
Real took the lead against Sevilla through defender Nacho Fernandez's quickly-taken free-kick early on - a goal that saw Zidane's men break Bayern Munich's record after scoring in their 62nd consecutive game.
Ronaldo hadn't played an away match in the league since March, a run of four straight games. The Welshman is being struggling with injuries during the current campaign and is now working to recover in time for the Champions League final against Juventus on the 3 of June.
Facundo Roncaglia tackled Isco on the edge of the area, only for the ball to drop kindly for Ronaldo, who hammered a ferocious left-footed drive through Gustavo Cabral's legs and beyond the helpless Sergio Alvarez. I have rested a bit more this year, to be good at the end of the season.
"But I am doing well and helping the team with goals at the moment, so I am happy".
"We must play very well and like we did in our (victorious) Copa del Rey tie to be able to overcome them".
The Portuguese star scored within 10 minutes of kick-off and his goal brought more weight than just the La Liga title race.
Leganes' draw and the point claimed by Deportivo La Coruna in Villarreal means that Sporting Gijon are relegated to the second division despite a 1-0 win away to Eibar thanks to a first half goal from Burgui.
Having soaked up that pressure, a deadly Real counter-attack doubled their advantage just three minutes into the second period.
With Real comfortably leading, Zidane withdrew Ronaldo and Isco for Marcos Asensio and Lucas Vazquez in the 84th minute.