Mexico won in Columbus for the first time, beating the U.S. 2-1 in November, and the Americans will be looking to return serve in Mexico City after securing a 2-0 win over Trinidad & Tobago on Thursday.
FIFA.com takes a closer look at all the action from Matchday 5, as the fifth and final round of CONCACAF qualifying reaches the halfway stage.
El Tri's victor came just before half-time through an Oswaldo Alanis header from a Mexico corner. In the 63rd minute, Herrera found a streaking Hirving Lozano, who was able to get behind the Honduras backline and finish a breakaway to give Mexico a 2-0 lead.
Mexico is in first place in the group with 10 points.
Mexico was finally able to completely kill the game off when Mexico scored two goals inside three minutes. It erased a disappointing opening half that saw Trinidad and Tobago forward Kenwyne Jones create the best chance before the break with a close-range header that struck the crossbar.
Honduras lost 6-0 against U.S. in March and tied Costa Rica 1-1.
The sixth round of qualifying in North and Central America will be held from 12 to 14 June. Midway through the qualifying campaign, US occupy the final qualifying berth, sitting just one point above fourth-placed Panama and there are no doubts they will be under pressure when facing leaders Mexico.
The number - the number of clean sheets that Mexico has recorded in their last four matches in the Hexagonal. Chivas defender Oswaldo Alanis gave Mexico the advantage from a corner, and El Tri continued to make easy work of a Honduran side whose World Cup dream is all but over.
"These games are tough". Results appear to have improved under Bruce Arena, as USMNT went on to defeat Honduras and Trinidad and Tobago at home while sharing spoils with Panama on the road, but there is still a lot of work to be done.