UEFA powers France and England squared off in Paris to close their worldwide fixture windows, and they went back and forth in an entertaining affair, with Les Bleus climbing back into the lead and holding on for a 3-2 victory through Borussia Dortmund rising star Ousmane Dembele.
But it was only a brief respite for England as Dembele scored the victor 12 minutes from time with a low shot into the bottom corner after mistakes by the England defence.
Gareth Southgate was frustrated by England's display on a night when not even the video assistant referee could help prevent a deserved defeat to France.
England had actually taken the lead at the Stade de France when Kane scored after only eight minutes.
But a dazzling France attack, led by Monaco sensation Kylian Mbappe, continued to tear holes in the England defence despite the numerical disadvantage and Borussia Dortmund winger Ousmane Dembele became the third home player to score a maiden global goal when he sealed victory 12 minutes from time.
France boss Didier Deschamps came in for criticism after Saturday's (AEST) defeat to Sweden that put its FIFA World Cup qualification hopes in jeopardy and he responded by fielding a team packed with youthful attacking verve. "With the ball we caused a lot of problems, took our first goal very well", he said.
Monaco's (for now) 18-year-old sensation Kylian Mbappe set up Ousmane Dembele for the victor in the 78th minute, giving 10-man France a 3-2 victory.
On a frustrating night: "We should have got a result".
48' - GOAL! France 2-2 England (Kane pen) Clever from Kane - Lloris dives right, he smacks into the middle- unusually for him, but he knows Lloris knows him - and suddenly, England are strong favourites! But I think we've had to play at our absolute limit to stay in all three of the matches, which has shown in the latter stages of those games.
Monaco sensation Kylian Mbappe was often to the fore as Les Bleus made the most of an England side still getting to grips with 3-4-3, although defenders Umtiti and Sidibe were the beneficiaries before half-time. We've got to find a way to win, especially when they went down to 10 men. We need to see the reality of where we are, test yourself against the best, so you don't mask where you are in terms of (being) a team.