But Ostapenko, 20, was the youngest player left in the tournament and Venus has scythed through the draw by dispatching a series of opponents nearly half her age, many of whom idolised the seven-time Grand Slam champion when they were growing up.
"I think we both play a good match, but at the end, I think just two points that decided the match". She started the year making the Australian Open final and ever since has been strong on all surfaces, making the final stages of most tournaments she has entered. The German whose form seemed to have picked up in the last two weeks of competition, failed to take control after winning the first set.
All along, Williams's serve could bail her out of inconveniences. Spain's No. 15-ranked Garbine Muguruza, the 2016 French Open champion and 2015 Wimbledon finalist, overcame a No. 1 player presumed shaky through this fortnight.
Earlier Monday, No. 7 seed Svetlana Kuznetsova became the first player to reach the quarterfinals as the two-time Grand Slam champion from Russian Federation beat ninth-seeded Agnieszka Radwanska of Poland 6-2, 6-4.
After repeatedly digging himself out of hard situations, Nadal finally succumbed, broken in the last game of a 6-3, 6-4, 3-6, 4-6, 15-13 loss to Muller on Monday. The seventh-seeded Croat beat Roberto Bautista Agut 6-2, 6-2, 6-2. Halep also advanced Monday, while Pliskova lost in the second round.
The 20-year-old Latvian, listed by the WTA as Jelena Ostapenko, has frequently been called Alona during Wimbledon.
Ostapenko had never before been past the third round at a major tournament prior to this year's French Open.
Svetlana Kuznetsova became the first player to reach the quarterfinals at Wimbledon. The Indo-Belgian pair went down 2-6, 4-6 in 72-minutes.
"I didn't know. I was not on Henman Hill, I was on Court 1 playing", Konta said after being told of what had happened.
As Wimbledon entered its second week, the men's and women's draw seemed to inhabit disparate worlds. "The scheduling has stayed the same on this day since I've been around".
Until previous year, Williams had not progressed beyond the quarters since 2009, but the five-time victor has now managed consecutive appearances in the last four, having beaten her Latvian opponent 6-3, 7-5 in 75 minutes on Centre Court.