The match turned out to be a seesaw of performances from both the sides - an entertaining game where the momentum kept shifting in every session.
If there are two flies in England's ointment after Joe Root's first series victory in which he led wonderfully well for a novice, one is that England have yet to break the mould whereby they bat feebly - buckling under scoreboard pressure - after bowling first.
Jennings mustered 18, rounding out his series average at 15.88 in eight innings, while Westley and Malan's respective nine and six followed innings of 29 and 18 first time round here. He also became the third youngest batsman and 22nd Englishman to surpass the milestone.
Bairstow had missed a stumping in South Africa's first innings but his mistakes are rare, while Stokes at slip has been nearly infallible; and Alastair Cook's catch at second slip was top-drawer. He could not get his century but took England's score to 362. It is a luxury to have Moeen there but it is also a huge strength of England's team to have a proper batsman in that position.
Anderson will return on Sunday one wicket short of his 23rd career five-for, and his first in front of the James Anderson end.
England was in control for nearly the whole day, except for a short period at the start when South Africa took three wickets in five overs to have England at 312-9.
Bayliss' side face West Indies over three Tests starting later this month, before heading Down Under for the Ashes, and the Australian is still a long way from being able to choose reliable operators to help shoulder the burden weighing heavily on Root and Alastair Cook.
It was a odd series for the batsmen on both sides with only 3 centuries being scored and England gaining a batting advantage largely through the costly number of catches the Proteas put down.
Duanne Olivier - 7/10 - Encouraging display from the young bowler as he took 2-91 in the first innings then eclipsed it with 3-38 in the second.
They would not even crossed 200 mark, if only Moeen Ali had not scored a courageous 75 not out in just 66 deliveries sending 9 deliveries to boundary and 3 for sixers.
"It's been very enjoyable the majority of the time", he said.
It was comfortable in the end, but it would not have been greedy of England to expect an even more comprehensive win, given how dominant their senior seamers, James Anderson and Stuart Broad, had been at the start of South Africa's chase.
SOUTH AFRICA: D Elgar, HG Kuhn, HM Amla, Q de Kock (wk), F du Plessis (capt), T Bavuma, TB de Bruyn, KA Maharaj, K Rabada, M Morkel, D Olivier.
Except for a two-hour period when Faf du Plessis and Hashim Amla were together between lunch and tea, the Proteas showed little stomach for this fight - it was a pathetic capitulation. The duo built the fourth 100-run stand for South Africa in the series.
"It is a challenge for Vern because it's happened too often that he doesn't play a full series", du Plessis explained.
Paulami Chakraborty, a singer, dancer, artist, and photographer, loves the madness of cricket and writes about the game.